解剖学报

›› 2009, Vol. 40 ›› Issue (6): 954-957.doi: 10.3969/j.issn.0529-1356.2009.06.021

• 论著 • 上一篇    下一篇

转化生长因子β受体在小鼠胚胎心流出道的表达

刘慧霞1;景宜馨2; 郭健津2 ;张紫燕2 ;李海荣1 ;杨艳萍1 ;张涛1;景雅1*   

  1. 1. 山西医科大学组织胚胎学教研室，太原 030001;2. 山西医科大学临床医学专业，太原 030001
  • 收稿日期:2008-04-07 修回日期:2008-06-17 出版日期:2009-12-06
  • 通讯作者: 景雅

Expression of transforming growth factor-β receptors in the outflow tract of mouse embryonic heart

  1. 1. Department of Histology and Embryology, Shanxi Medical University, Taiyuan 030001, China; 2. Department of Clinic Medicine, Shanxi Medical University, Taiyuan 030001,China
  • Received:2008-04-07 Revised:2008-06-17 Online:2009-12-06
  • Contact: JING Ya

关键词: 流出道, 发育, 转化生长因子β受体, 免疫组织化学, 小鼠

Abstract: Objective To investigate the spatiotemporal expression patterns of transforming growth factor-β(TGF-β) receptors type Ⅰ and type Ⅱ and their relationships with development of outflow tract(OFT) in mouse embryonic heart. Methods Serial sections of mouse embryos from embryonic day 9 (E9d) to embryonic day 14 (E14d) were stained using PAP immunohistochemical methods. Results Expressions of TGF-β receptors type Ⅰ (TGF-βRⅠ) and type II(TGF-βRⅡ) in the myocardial wall of OFT started at E10d, reached the reflection with splanchnic epithelium on the dorsal wall of the pericardial cavity at E11d. At E12d, expression intensity of TGF-βRⅠ and TGF-βRⅡ in myocardium increased to its highest level, and TGF-βRⅡ positive mesenchymal cells in OFT ridges could be detected. After E13d the staining intensity of TGF-βRⅠ and TGF-βRⅡ decreased rapidly，

Key words: Outflow tract, Development, Transforming growth factor-β receptor, Immunohistochemistry, Mouse

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